Formula 82M

A Uniquely Engineered Formulation Providing an Alternative Solution for Hair Loss


Minoxidil has been the number one topical therapy for Androgenetic Alopecia (AGA) since receiving FDA clearance in 1988. Minoxidil Sulfate is an active metabolite which has been shown to stimulate hair growth.

Formula 82M contains (5%) Minoxidil and Tretinoin, and a 5-alpha reductase blocker and topical steroid to improve efficacy and reduce irritation, complimented by other proprietary ingredients to improve the formula's overall effectiveness, stability and usability.

Proposed mechanisms of action for Minoxidil:

  • Creates Vasodilatation
  • Slows Senescence of Keratinocytes
  • Increases Proliferation of Dermal Papilla Cells in the Hair Follicle
  • Enhances Cell Proliferation

Increased Efficacy With Tretinoin And Minoxidil

"So why does this product appear markedly more efficacious than others on the market such as Rogaine® and Propecia®? A review of product ingredients discussed in this article shows that higher strengths of Minoxidil (5%) are more effective than lower (2%). The addition of Tretinoin increases the efficacy of Minoxidil. A topical steroid improves efficacy and reduces irritation, and a 5-alpha reductase blocker increases efficacy. Formula 82M contains all of these previously proven ingredients and now in a Propylene Glycol-free base. However, more importantly, their proprietary solubilizing and stabilizing process appears to markedly improve drug delivery and shelf life. This article is meant to serve as a preliminary overview of the Formula 82M topical formulation for Androgenetic Alopecia. I am continuing to evaluate this formulation, which is currently being made available by prescription in the U.S. through MasterPharm Compounding Pharmacy."

— Dr. Mark G. Rubin
From 82M, A Uniquely Engineered Formulation Providing an Alternative Solution for Alopecia Patients